Leptin and IGF-1 in infancy are associated with variants in DHCR7 and CYP2R1 that relate with type 1 diabetes and 25OHD.

Antigoni Eleftheriou Ken K Ong Ieuan A Hughes Clive J Petry

Published in: The Journal of clinical endocrinology and metabolism (2023)

The vitamin D metabolism genes DHCR7 and CYP2R1 might influence infancy leptin and IGF-1 levels respectively. These findings open the possibility for a developmental role of vitamin D that is mediated by growth-related hormones with implications for the onset of type 1 diabetes autoimmunity.

Keyphrases

weight gain
binding protein
pi k akt
growth hormone
copy number
minimally invasive
genome wide
bioinformatics analysis
dna methylation
genome wide identification