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Leptin and IGF-1 in infancy are associated with variants in DHCR7 and CYP2R1 that relate with type 1 diabetes and 25OHD.

Antigoni EleftheriouKen K OngIeuan A HughesClive J Petry
Published in: The Journal of clinical endocrinology and metabolism (2023)
The vitamin D metabolism genes DHCR7 and CYP2R1 might influence infancy leptin and IGF-1 levels respectively. These findings open the possibility for a developmental role of vitamin D that is mediated by growth-related hormones with implications for the onset of type 1 diabetes autoimmunity.
Keyphrases
  • weight gain
  • binding protein
  • pi k akt
  • growth hormone
  • copy number
  • minimally invasive
  • genome wide
  • bioinformatics analysis
  • dna methylation
  • genome wide identification