Leptin and IGF-1 in infancy are associated with variants in DHCR7 and CYP2R1 that relate with type 1 diabetes and 25OHD.
Antigoni EleftheriouKen K OngIeuan A HughesClive J PetryPublished in: The Journal of clinical endocrinology and metabolism (2023)
The vitamin D metabolism genes DHCR7 and CYP2R1 might influence infancy leptin and IGF-1 levels respectively. These findings open the possibility for a developmental role of vitamin D that is mediated by growth-related hormones with implications for the onset of type 1 diabetes autoimmunity.