Tumor Microenvironment Stimuli-Responsive Fluorescence Imaging and Synergistic Cancer Therapy by Carbon-Dot-Cu2+ Nanoassemblies.
Shan SunQiao ChenZhongdi TangChuang LiuZhongjun LiAiguo WuHengwei LinPublished in: Angewandte Chemie (International ed. in English) (2020)
A method is developed to fabricate tumor microenvironment (TME) stimuli-responsive nanoplatform for fluorescence (FL) imaging and synergistic cancer therapy via assembling photosensitizer (chlorine e6, Ce6) modified carbon dots (CDs-Ce6) and Cu2+ . The as-obtained nanoassemblies (named Cu/CC nanoparticles, NPs) exhibit quenched FL and photosensitization due to the aggregation of CDs-Ce6. Their FL imaging and photodynamic therapy (PDT) functions are recovered efficiently once they entering tumor sites by the stimulation of TME. Introducing of Cu2+ not only provides extra chemodynamic therapy (CDT) function through reaction with hydrogen peroxide (H2 O2 ), but also depletes GSH in tumors by a redox reaction, thus amplifying the intracellular oxidative stress and enhancing the efficacy of reactive oxygen species (ROS) based therapy. Cu/CC NPs can act as a FL imaging guided trimodal synergistic cancer treatment agent by photothermal therapy (PTT), PDT, and thermally amplified CDT.
Keyphrases
- cancer therapy
- photodynamic therapy
- fluorescence imaging
- drug delivery
- reactive oxygen species
- hydrogen peroxide
- high resolution
- oxidative stress
- energy transfer
- aqueous solution
- quantum dots
- nitric oxide
- metal organic framework
- dna damage
- cell death
- stem cells
- bone marrow
- single molecule
- endoplasmic reticulum stress
- ischemia reperfusion injury
- induced apoptosis
- heat stress