Retrospective Review of Virologic and Immunologic Response in Treatment-Experienced Patients on Third-Line HIV Therapy in Lusaka, Zambia.
Paul Msanzya ZuluMona-Gekanju ToequeLottie HachaambwaLameck ChirwaSombo FwoloshiMpanji SiwingwaMelody MbeweJoelle I RosserKristen A StaffordBrianna LindsayLloyd MulengaCassidy Wayne ClaassenPublished in: Journal of the International Association of Providers of AIDS Care (2021)
Established antiretroviral therapy (ART) programs in sub-Saharan Africa have well-defined first-and second-line therapies but no standard third-line ART regimen. The impact of third-line ART on patients with multiclass-resistant HIV in resource-limited settings has not been well characterized. We conducted a retrospective review of patients on third-line ART at the University Teaching Hospital in Lusaka, Zambia. We assessed virologic and immunologic outcomes following 6 months of third-line therapy and found among those with a documented viral load, viral suppression (≤1000 copies/ml) at 24 weeks was 95% (63/66) with a mean increase in CD4 count of 116 cells/mm3 and viral suppression of 63% (63/100) by imputation of missing data. This study suggests that third-line therapy is clinically and virologically effective among patients with multiclass-resistance in a resource-limited setting in sub-Saharan Africa.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv infected patients
- hiv positive
- human immunodeficiency virus
- hiv aids
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- peritoneal dialysis
- sars cov
- prognostic factors
- mesenchymal stem cells
- induced apoptosis
- public health
- bone marrow
- stem cells
- electronic health record
- signaling pathway
- big data
- pi k akt
- deep learning
- south africa
- cell proliferation
- oxidative stress
- smoking cessation