The C-terminus of Gain-of-Function Mutant p53 R273H Is Required for Association with PARP1 and Poly-ADP-Ribose.

Devon Lundine George K Annor Valery Chavez Styliana Maimos Zafar Syed Shuhong Jiang Viola Ellison Jill Bargonetti

Published in: Molecular cancer research : MCR (2022)

The C-terminal region of mtp53 confers GOF activity that mediates mtp53-PARP1 and PAR interactions assisting DNA replication, thus implicating new biomarkers for PARP inhibitor therapy.

Keyphrases

dna damage
dna repair
oxidative stress
cell therapy
smoking cessation