Co-targeting WIP1 and PARP induces synthetic lethality in hepatocellular carcinoma.

Miaoqin ChenWeikai WangShiman HuYifan TongYiling LiQi WeiLei YuLiyuan ZhuYiran ZhuLeiming LiuZhenyu JuXian WangHongchuan JinLifeng Feng

Published in: Cell communication and signaling : CCS (2022)

WIP1 plays an oncogenic effect in HCC development, and targeting WIP1-dependent DNA damage repair alone or in combination with PARP inhibition might be a reasonable strategy for HCC management. Video abstract.

Keyphrases

dna damage
dna repair
oxidative stress
cancer therapy
transcription factor