Proteomic Characterization of Middle Ear Fluid Confirms Neutrophil Extracellular Traps as a Predominant Innate Immune Response in Chronic Otitis Media.

Stephanie ValMarian PoleyKristy BrownRachel ChoiStephanie JeongAnnie Colberg-PoleyMary C RoseKaruna C PanchapakesanJoe C DevaneyMarcos Perez-LosadaDiego A Preciado

Published in: PloS one (2016)

Proteomic analysis of MEEs revealed a predominantly neutrophilic innate mucosal response in which MUC5B is associated with NET DNA. NETs are a primary macromolecular constituent of human COM middle ear effusions.

Keyphrases

immune response
endothelial cells
dendritic cells
label free
toll like receptor
circulating tumor
induced pluripotent stem cells
single molecule
cell free
single cell