The SARS-CoV-2 Spike protein induces long-term transcriptional perturbations of mitochondrial metabolic genes, causes cardiac fibrosis, and reduces myocardial contractile in obese mice.
Xiaoling CaoVi NguyenJoseph TsaiChao GaoYan TianYuping ZhangWayne CarverHippokratis KiarisTaixing CuiWenbin TanPublished in: bioRxiv : the preprint server for biology (2023)
Our data demonstrated that the Spike protein could induce long-term transcriptional suppression of mitochondria metabolic genes and cause cardiac fibrosis and myocardial contractile impairment, providing mechanistic insights to PACS-related cardiomyopathy.
Keyphrases
- left ventricular
- sars cov
- skeletal muscle
- genome wide
- gene expression
- transcription factor
- heart failure
- protein protein
- genome wide identification
- smooth muscle
- oxidative stress
- bioinformatics analysis
- cell death
- amino acid
- binding protein
- electronic health record
- heat shock
- dna methylation
- small molecule
- atrial fibrillation
- genome wide analysis
- deep learning
- heat shock protein