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Pestiocandin, a new papulacandin class antibiotic isolated from Pestalotiopsis humus.

Katsuyuki SakaiTakuya SugaMasato IwatsukiTakumi ChinenKenichi NonakaTakeo UsuiYukihiro AsamiSatoshi ŌmuraKazuro Shiomi
Published in: The Journal of antibiotics (2018)
Secondary metabolites of microorganisms have proven to be an excellent source of drugs. We isolated a new antibiotic, named pestiocandin (1), from a culture broth of a filamentous fungus, Pestalotiopsis humus FKI-7473, using a multidrug-sensitive budding yeast, S. cerevisiae 12geneΔ0HSR-iERG6. The structure of 1 was elucidated by various NMR studies. All geometric isomerisms of 1 were shown to be the E-form and two pyranose units of 1 were found to be glucose and galactose types. Compound 1 showed weak growth inhibition against Gram-positive and Gram-negative bacteria, yeasts and a filamentous fungus. It displayed more potent growth inhibition against multidrug-sensitive yeasts than wild-type yeasts.
Keyphrases
  • saccharomyces cerevisiae
  • wild type
  • drug resistant
  • magnetic resonance
  • ms ms
  • high resolution
  • gram negative
  • copy number
  • genome wide
  • adipose tissue
  • blood pressure
  • anti inflammatory
  • genome wide identification