Enantioselective Au(I)-catalyzed dearomatization of 1-naphthols with allenamides through Tethered Counterion-Directed Catalysis.

Yunliang YuZhenhao ZhangArnaud VoituriezNicolas RabassoGilles Frison Angela Marinetti Xavier Guinchard

Published in: Chemical communications (Cambridge, England) (2021)

The Tethered Counterion-Directed Catalysis (TCDC) approach has been applied to the enantioselective Au(I) catalyzed dearomatizations of 1-naphthols with allenamides. Stereocontrol is ensured by the intramolecular ion-pairing between the chiral gold-tethered phosphate and an iminium unit, that provides a rigid, well-defined chiral environment to the key electrophilic intermediate.

Keyphrases

visible light
room temperature
sensitive detection
ionic liquid
capillary electrophoresis
reduced graphene oxide
mass spectrometry