The Compatibility of Alisma and Atractylodes Affects the Biological Behaviours of VSMCs by Inhibiting the miR-128-5p/p21 Gene.

Wei WeiYang Jie ZhouJu Lian ShenLu LuXin Ru LvTao Tao LuPei Tao XuXie Hua Xue

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

Our research showed that the migration, phenotypic transformation, and proliferation of ox-LDL-induced VSMCs were repressed by AA through inhibiting miR-128-5p by targeting the p21 gene, which may provide an effective option for the treatment of atherosclerosis.

Keyphrases

signaling pathway
genome wide
copy number
vascular smooth muscle cells
cardiovascular disease
genome wide identification
high glucose
diabetic rats
gene expression
dna methylation
type diabetes
drug induced
low density lipoprotein
endothelial cells
genome wide analysis
replacement therapy