Shiga toxin 2 from enterohemorrhagic Escherichia coli induces reactive glial cells and neurovascular disarrangements including edema and lipid peroxidation in the murine brain hippocampus.
Clara BerdascoAlipio PintoValeria CalabróDavid ArenasAdriana CangelosiPatricia GeogheganPablo EvelsonJorge GoldsteinPublished in: Journal of biomedical science (2019)
Systemic sublethal administration of Shiga toxin 2 produced a deterioration of the cells that integrate the vascular unit displaying astrocytic and microglial reactive profiles, while edema and lipid peroxidation were also observed. The contribution of lipopolysaccharide to pathogenicity caused by Shiga toxin 2 resulted to enhance the observed hippocampal damage.
Keyphrases
- escherichia coli
- induced apoptosis
- biofilm formation
- cell cycle arrest
- klebsiella pneumoniae
- cerebral ischemia
- neuropathic pain
- oxidative stress
- endoplasmic reticulum stress
- toll like receptor
- signaling pathway
- white matter
- immune response
- resting state
- staphylococcus aureus
- lipopolysaccharide induced
- spinal cord injury
- pseudomonas aeruginosa
- prefrontal cortex