Pharmaceutical Emulsions: A Viable Approach for Ocular Drug Delivery.
Amol Chhatrapati BisenSaurabh SrivastavaAnjali MishraSachin Nashik SanapArpon BiswasAbhijit Deb ChoudhuryAyush DubeyNeeraj Mohan GuptaKaran Singh YadavMadhav Nilakanth MugaleRabi Sankar BhattaPublished in: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (2024)
Ocular disorders can lead to serious sight impairment and irreversible blindness. Generally simple topical and systemic treatments are recommended for treating these vision-threatening illnesses. The distinctive architecture of the eye complicates ocular drug delivery. The ophthalmic emulsion formulations have been found to increase bioavailability in the eye by prolonging residence time and improving permeability through the cornea. Therefore, this study highlights ophthalmic emulsions meant for both the anterior and posterior parts of the eye while examining a wide range of ocular disorders that affect individuals globally. This review presents, in brief, recent emulsion-based patented innovations, clinical trials, and marketed emulsion formulations for ocular drug delivery, which are strengthening development of the new ophthalmic drug products for managing different ocular diseases and disorders.