LncGBP9 knockdown alleviates myocardial inflammation and apoptosis in mice with acute viral myocarditis via suppressing NF-κB signaling pathway.
Yimin XueJiuyun ZhangJun KeLijuan ZengKun ChengXu HanFalu ChenFeng ChenPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2022)
Collectively, lncGBP9 knockdown exerts anti-inflammatory and anti-apoptotic effects in CVB3-induced AVMC, which may be mediated in part via NF-κB signaling pathway. These findings highlight lncGBP9 as an attractive target for therapeutic interventions.
Keyphrases
- signaling pathway
- anti inflammatory
- pi k akt
- oxidative stress
- cell cycle arrest
- cell death
- diabetic rats
- induced apoptosis
- epithelial mesenchymal transition
- drug induced
- liver failure
- high glucose
- sars cov
- endoplasmic reticulum stress
- physical activity
- left ventricular
- respiratory failure
- high fat diet induced
- mouse model
- heart failure
- hepatitis b virus
- metabolic syndrome
- atrial fibrillation
- wild type