Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation.
Cansu TekinHella L AbersonCynthia WaasdorpGerrit K J HooijerOnno J de BoerFrederike DijkMaarten F BijlsmaC Arnold SpekPublished in: Cellular oncology (Dordrecht) (2020)
Macrophages secrete MMP9, which acts upon PDAC cell PAR1 to induce mesenchymal transition. This macrophage-induced mesenchymal transition supports the tumor-promoting role of macrophage influx, explaining the dichotomous contributions of these immune cells to tumor growth.