Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation.

Cansu TekinHella L AbersonCynthia WaasdorpGerrit K J HooijerOnno J de BoerFrederike DijkMaarten F BijlsmaC Arnold Spek

Published in: Cellular oncology (Dordrecht) (2020)

Macrophages secrete MMP9, which acts upon PDAC cell PAR1 to induce mesenchymal transition. This macrophage-induced mesenchymal transition supports the tumor-promoting role of macrophage influx, explaining the dichotomous contributions of these immune cells to tumor growth.

Keyphrases

bone marrow
stem cells
adipose tissue
single cell
cell migration
high glucose
cell therapy
diabetic rats
mesenchymal stem cells
drug induced