An ancient respiratory enzyme metabolically modulates Fusobacterium nucleatum virulence.
Timmie A BrittonChenggang WuYi-Wei ChenDana FranklinYimin ChenMartha I CamachoTruc T LuongAsis DasHung Ton-ThatPublished in: bioRxiv : the preprint server for biology (2023)
metabolism and virulence as genetic disruption of Rnf causes pleiotropic defects in polymicrobial interaction, biofilm formation, cell growth and morphology, hydrogen sulfide production, and ATP synthesis. Targeted metabolomic profiling demonstrates that the loss of this highly conserved respiratory enzyme significantly diminishes catabolism of numerous amino acids, which negatively impacts fusobacterial virulence as tested in a preterm birth model in mice.
Keyphrases
- biofilm formation
- preterm birth
- pseudomonas aeruginosa
- staphylococcus aureus
- escherichia coli
- candida albicans
- low birth weight
- cystic fibrosis
- amino acid
- gestational age
- antimicrobial resistance
- transcription factor
- single cell
- type diabetes
- gene expression
- dna methylation
- cancer therapy
- high fat diet induced
- oxidative stress
- dna damage
- adipose tissue
- wild type