Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma.
Michael D KinnamanSimone ZaccariaAlvin P Makohon-MooreBrian J ArnoldMax Fine LevineGunes GundemJuan Esteban Arango OssaDominik GłodzikM Irene Rodríguez-SánchezNancy BouvierShanita LiEmily StockfischMarisa DuniganCassidy CobbsUmeshkumar K BhanotDaoqi YouKatelyn MullenJerry P MelchorMichael V OrtizTara J O'DonohueEmily K SlotkinLeonard H WexlerFilemon Dela CruzMeera R HameedJulia L Glade BenderWilliam D TapPaul A MeyersElli PapaemmanuilAndrew L KungChristine A Iacobuzio-DonahuePublished in: Cancer research (2023)
The chemoresistant population in recurrent osteosarcoma is subclonal at diagnosis, emerges at the time of primary resection due to selective pressure from neoadjuvant chemotherapy, and is characterized by unique oncogenic amplifications.