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Preclinical Evaluation of B7-H3-specific Chimeric Antigen Receptor T Cells for the Treatment of Acute Myeloid Leukemia.

Eben I LichtmanHongwei DuPeishun ShouFeifei SongKyogo SuzukiSarah AhnGuangming LiSoldano FerroneLishan SuBarbara SavoldoGianpietro Dotti
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
B7-H3 is a promising target for AML-directed CAR-T therapy. B7-H3.CAR-Ts control AML and have a favorable safety profile in preclinical models.
Keyphrases
  • acute myeloid leukemia
  • allogeneic hematopoietic stem cell transplantation
  • cell therapy
  • stem cells
  • acute lymphoblastic leukemia
  • mesenchymal stem cells