Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis.
M J NielsenD ThorburnD J LeemingJ R HovS NygårdB MoumF SaffiotiO H GiljaK M BobergG MazzaH RøsjøM PinzaniT H KarlsenM A KarsdalMette VesterhusPublished in: Alimentary pharmacology & therapeutics (2018)
Extracellular matrix remodeling is elevated in primary sclerosing cholangitis patients compared to ulcerative colitis patients. Furthermore, the interstitial matrix marker PRO-C3 was identified as a potent prognostic marker and an independent predictor of transplant-free survival in primary sclerosing cholangitis.