The quorum sensing peptide EntF* promotes colorectal cancer metastasis in mice: a new factor in the host-microbiome interaction.
Evelien WynendaeleNathan DebunneYorick JanssensAnton De SpiegeleerFrederick VerbekeLiesa TackSophie Van WeldenEvy GoossensDaniel KnappeRalf HoffmannChristophe Van De WieleDebby LaukensPeter Van EenooLars VereeckeFilip Van ImmerseelOlivier De WeverBart De SpiegeleerPublished in: BMC biology (2022)
Our work identifies a new class of molecules, quorum sensing peptides, as potential regulators of host-microbe interactions. We prove, for the first time, the presence of a selected quorum sensing peptide metabolite in a mouse model, and we demonstrate its effects on colorectal cancer metastasis. We believe that our work represents a starting point for future investigations on the role of microbiome in colorectal cancer metastasis and for the development of novel bio-therapeutics in other disease areas.