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Cyclin-Dependent Kinase 4/6 Inhibitor Outcomes in Patients With Advanced Breast Cancer Carrying Germline Pathogenic Variants in DNA Repair-Related Genes.

Luisina BrunoAlexis OstinelliFederico WaisbergDiego EnricoCarolina PonceSergio RiveroAlbano BlancoMartín ZarbaMartín LozaVerónica FabianoMora AmatMaría Teresa PomboLaura NoroMatías ChacónFederico ColóReinaldo ChacónJorge NadalAdrián NervoVictoria Costanzo
Published in: JCO precision oncology (2022)
pathogenic variants were independently associated with poor outcomes in patients with advanced breast cancer treated with CDK4/6 inhibitors.
Keyphrases
  • dna repair
  • dna damage
  • copy number
  • cell cycle
  • dna damage response
  • type diabetes
  • cell death
  • genome wide
  • glycemic control
  • newly diagnosed