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Conjugated anionic PEG-citrate G2 dendrimer with multi-epitopic HIV-1 vaccine candidate enhance the cellular immune responses in mice.

Asghar AbdoliNina RadmehrAzam BolhassaniAkram EidiParvaneh MehrbodFatemeh MotevalliZahra KianmehrMohsen ChianiMehdi MahdaviShaghayegh YazdaniMehdi Shafiee ArdestaniMohammad Reza KandiMohammad Reza Aghasadeghi
Published in: Artificial cells, nanomedicine, and biotechnology (2017)
Multi-epitope vaccines might cause immunity against multiple antigenic targets. Four immunodominant epitopes of HIV-1 genome were used to construct a polytope vaccine, formulated by dendrimer. Two regimens of polytopes mixture with dendrimer were utilized to immunize BALB/c mice. Adjuvants were also used to boost immune responses. The conjugated polytope could arouse significant cellular immune responses (P < 0.05) and Th1 response showed higher intensity compared to Th2 (P < 0.05). Our study depicted that conjugated dendrimer with multi-epitopic rHIVtop4 would efficiently induce cell-mediated immune responses and might be considered as promising delivery system for vaccines formulation.
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