Antioxidant properties of ALD grown nanoceria films with tunable valency.
Ankur GuptaTamil S SakthivelCraig J NealSupriya KoulSushant SinghAkihiro KushimaKenneth W LiechtyPublished in: Biomaterials science (2019)
Herein, we provide the first account of a method to control cerium oxide's mixed valence states (as Ce3+ to Ce4+ ratio) in ultra-thin films formed via atomic layer deposition (ALD). It is determined that modulation of Ce3+/Ce4+ ratio occurs with respect to film thickness and is analogous to the change in surface chemistry observed for cerium oxide nanoparticles with varying particle diameter. The influence of film thickness on enzyme-mimetic radical scavenging is also characterized. Higher film thicknesses show 9-fold increase in catalytic activity. In vitro biocompatibility (apoptosis < 4%) and electrochemical biosensing (lowest concentration: 18 ppt) studies were performed to demonstrate the potential of ALD-grown nanoceria films for biomedical applications.
Keyphrases
- oxide nanoparticles
- room temperature
- energy transfer
- reduced graphene oxide
- oxidative stress
- ionic liquid
- optical coherence tomography
- gold nanoparticles
- high resolution
- label free
- endoplasmic reticulum stress
- cell death
- cell cycle arrest
- quantum dots
- optic nerve
- mass spectrometry
- cell proliferation
- carbon nanotubes
- signaling pathway
- simultaneous determination