Fosfomycin single- and multiple-dose pharmacokinetics in patients undergoing prolonged intermittent renal replacement therapy.

Lisa K V GereckeJulius J SchmidtCarsten HaferGabriele EdenStefanie M Bode-BögerJens Martens-LobenhofferTobias WelteJan T Kielstein

Published in: The Journal of antimicrobial chemotherapy (2021)

Patients undergoing PIRRT experience significant fosfomycin elimination, requiring a dose of 5 g/8 h to reach adequate plasma levels. However, drug accumulation may occur, depending on dialysis frequency and intensity.

Keyphrases

patients undergoing
high intensity
urinary tract infection
acute kidney injury
gram negative
chronic kidney disease
emergency department
multidrug resistant
adverse drug