Neuromedin B promotes chondrocyte differentiation of mesenchymal stromal cells via calcineurin and calcium signaling.

Marie MaumusGuillaume FonteneauMaxime RuizSaid AssouHassan BoukhaddaouiPhilippe PastoureauFrédéric De CeuninckChristian JorgensenDanièle Noël

Published in: Cell & bioscience (2021)

NMB is a newly described chondroinductive bioactive factor that upregulates the key chondrogenic transcription factor Sox9 through the modulation of Ca2+ signaling pathway and calcineurin activity.

Keyphrases

transcription factor
signaling pathway
mesenchymal stem cells
bone marrow
pi k akt
dna binding
stem cells
epithelial mesenchymal transition
genome wide identification
induced apoptosis
protein kinase
cell proliferation
oxidative stress
tissue engineering