The Protective Effects of Thymosin-β-4 in a Rat Model of Ischemic Acute Kidney Injury.

Ugur AksuOnur M YamanIbrahim GunerGulcan GuntasFuat SonmezGamze TanriverdiMediha EserAris CakirisSibel Akyolİsmail SeçkinHafize UzunNermin YelmenGulderen Sahin

Published in: Journal of investigative surgery : the official journal of the Academy of Surgical Research (2019)

These results suggest that Tβ4 has significant improving effects in ischemic acute kidney injury. This beneficial effect might be a result of the inhibition of extracellular matrix remodeling and apoptosis cascade via modulation in renal redox status and inflammation.

Keyphrases

acute kidney injury
extracellular matrix
oxidative stress
cardiac surgery
ischemia reperfusion injury
endoplasmic reticulum stress
cerebral ischemia
cell death
brain injury
signaling pathway