Effect of daridorexant on sleep architecture in patients with chronic insomnia disorder - A pooled post hoc analysis of two randomized Phase 3 clinical studies.

Tobias Di MarcoIna DjonlagicYves DauvilliersKolia SadeghiDavid LittleAlexandre N DattaJeffrey HubbardGöran HajakAndrew KrystalAntonio OlivieriLiborio ParrinoCorey B PuryearGary ZammitJacob DonoghueThomas E Scammell

Published in: Sleep (2024)

Daridorexant reduced EEG features associated with hyperarousal as indicated by reduced Wake-to-Wake transition probabilities and enhanced spectral features associated with drowsiness and sleep during Wake and N1.

Keyphrases

sleep quality
physical activity
phase iii
open label
double blind
optical coherence tomography
working memory
computed tomography
high density
contrast enhanced