Development of a polygenic risk score to improve screening for fracture risk: A genetic risk prediction study.
Vincenzo ForgettaJulyan Keller-BaruchMarie ForestAudrey DurandSahir Rai BhatnagarJohn P KempMaria NethanderDaniel EvansJohn A MorrisDouglas P KielFernando RivadeneiraHelena JohanssonNicholas C W HarveyDan MellströmMagnus K KarlssonCyrus CooperDavid M EvansRobert ClarkeJohn A KanisEric OrwollEugene V McCloskeyClaes OhlssonJoelle PineauWilliam D LeslieCelia M T GreenwoodJohn Brent RichardsPublished in: PLoS medicine (2020)
Our results suggest that the use of a polygenic risk score in fracture risk screening could decrease the number of individuals requiring screening tests, including BMD measurement, while maintaining a high sensitivity and specificity to identify individuals who should be recommended an intervention.