Proton pump inhibitor therapy in pediatric eosinophilic esophagitis: predictive factors and long-term step-down efficacy.
Carolina Gutierrez-JunqueraSonia Fernández-FernándezGloria Domínguez-OrtegaVíctor Vila MiravetRoger García-PuigEnrique La Orden-IzquierdoLuis Peña QuintanaJosefa Barrio TorresEnrique Medina BenítezRosaura LeisRuth García-RomeroAna Fernández de ValderramaRaquel Vecino LópezPaloma Donado Palencianull nullPublished in: Journal of pediatric gastroenterology and nutrition (2022)
We confirmed the efficacy of PPIs for a large cohort of children with EoE with sustained histological remission using a step-down strategy. Children with fibrostenotic phenotypes are less likely to respond to induction therapy. Furthermore, patients with complete initial histological remission are more likely to experience long-term histological remission.