Two new sarasinosides from marine sponge Petrosia nigricans .

Rohaidah L MamaChona D GelaniJan Mart T DaluzMylene M UyEmi OhtaShinji Ohta

Published in: Natural product research (2023)

Two new sarasinosides designated as 5,8-epoxysarasinoside ( 1 ) and 8,9-epoxysarasinoside ( 2 ) and four known sarasinosides were isolated from marine sponge Petrosia nigricans , collected off the coast of Lipata, Surigao City, Philippines (9°49' North, 125°27' East). The structures were determined through extensive 2D NMR spectroscopy and HRMS. Both compounds exhibited low cytotoxicity against the HCT116 (colon) and A549 (lung) cancer cell lines.

Keyphrases

high resolution
tertiary care
high resolution mass spectrometry
cell cycle arrest
cell death
cell proliferation
pi k akt
simultaneous determination