Association of a Type 2-Polarized T Cell Phenotype With Methotrexate Nonresponse in Patients With Rheumatoid Arthritis.

Drew SlauenwhiteSarah M McAlpineJohn G HanlyAnikó MalikIan D HaidlJean S MarshallThomas B Issekutz

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)

We observed a bias toward type 2-polarized T cell inflammatory responses in the peripheral blood of MTX-nonresponsive RA patients. Targeting the IL-13+CD4+ T cell pathway could be a new therapeutic strategy in RA patients whose disease remains resistant to MTX.

Keyphrases

end stage renal disease
ejection fraction
peripheral blood
newly diagnosed
chronic kidney disease
rheumatoid arthritis
prognostic factors
peritoneal dialysis
systemic lupus erythematosus
low dose
drug delivery
high dose
systemic sclerosis
patient reported outcomes
patient reported