Antibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients.
Ming-Han ChenMing-Ting HuangWen-Kuang YuShinn-Shing LeeJia-Horng WangTing-Jen R ChengMichael R BowmanShie-Liang HsiehPublished in: Journal of biomedical science (2019)
Anti-Dectin-2 MoAbs significantly inhibited HDM-induced allergic responses in vitro and therefore have the potential to become therapeutic agents in mite-induced allergic diseases.
Keyphrases
- peripheral blood
- high glucose
- dendritic cells
- allergic rhinitis
- diabetic rats
- end stage renal disease
- endothelial cells
- chronic kidney disease
- drug induced
- ejection fraction
- signaling pathway
- mesenchymal stem cells
- peritoneal dialysis
- risk assessment
- cell therapy
- regulatory t cells
- immune response
- lung function
- prognostic factors
- air pollution
- heavy metals