Immunovascular microenvironment in relation to prognostic heterogeneity of WNT/β-catenin-activated hepatocellular carcinoma.

Kosuke MatsudaYutaka KurebayashiYohei MasugiKen YamazakiAkihisa UenoHanako TsujikawaHidenori OjimaMinoru KitagoOsamu ItanoMasahiro ShinodaYuta AbeMichiie Sakamoto

Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2022)

In conclusion, the immune and vascular microenvironments are interrelated and are also correlated with clinicopathological heterogeneity in W/B subclass HCC. These results could inform clinical practice and translational research on the development of therapeutic stratification of HCCs.

Keyphrases

clinical practice
single cell
cell proliferation
stem cells
epithelial mesenchymal transition