Nanosecond pulsed electric field ablates rabbit VX2 liver tumors in a non-thermal manner.

Qing-Gang LiZhen-Guo LiuGang DongYing SunYa-Wen ZouXiao-Long ChenBin WuXin-Hua ChenZhi-Gang Ren

Published in: PloS one (2023)

nsPEFs can induce Hep3B cells apoptosis and ablate rabbit VX2 liver tumors in a non-thermal manner versus RFA. The ultrasound contrast agent can monitor immediate effect of nsPEF ablation. This study provides a basis for the clinical study of nsPEFs ablation of liver cancer.

Keyphrases

radiofrequency ablation
oxidative stress
magnetic resonance imaging
magnetic resonance
endoplasmic reticulum stress
cell death
clinical trial
computed tomography
cell proliferation
double blind
contrast enhanced ultrasound