Enantioselective Synthesis of Spiro[indolizidine-1,3'-oxindoles].
Maria PérezCarlos RamosLucia MassiSilvia GazzolaChiara TaglientiNihan YayikElies MolinsAntonio ViaynaFrancisco Javier LuqueJoan BoschMercedes AmatPublished in: Organic letters (2017)
A three-step procedure for the enantioselective synthesis of spiro[indolizidine-1,3'-oxindoles], consisting of a stereoselective cyclocondensation reaction between (S)-tryptophanol and a prochiral or racemic δ-oxoester, bromination of the resulting oxazolopiperidone lactam, and a final stereoselective spirocyclization, is reported.
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