Intraductal papillary neoplasm of the bile duct: Cytomorphologic and molecular features.
Kristin StendahlSyed M GilaniOlca BasturkPei HuiCarlie S SigelGuoping CaiPublished in: Cancer cytopathology (2022)
Our study demonstrated that IPNB cytology specimens were relatively cellular with a wide spectrum of cytomorphology; however, most cases harbored adenocarcinoma or high-grade dysplasia. The characteristic cytomorphologic features included papillary/complex papillary clusters of columnar cells with vacuolated cytoplasm, enlarged nuclei, and fine granular chromatin in relatively cellular specimens. KRAS mutations identified may have potential diagnostic and therapeutic implications.
Keyphrases
- high grade
- low grade
- clear cell
- fine needle aspiration
- induced apoptosis
- gene expression
- cell cycle arrest
- squamous cell carcinoma
- transcription factor
- dna damage
- ultrasound guided
- air pollution
- genome wide
- endoplasmic reticulum stress
- cell death
- cell proliferation
- wild type
- signaling pathway
- human health
- single molecule