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Physiologically Based Pharmacokinetic Modeling of Fimasartan, Amlodipine, and Hydrochlorothiazide for the Investigation of Drug-Drug Interaction Potentials.

Su Jin RheeHyun A LeeSoyoung LeeEunwoo KimInseung JeonIm-Sook SongKyung-Sang Yu
Published in: Pharmaceutical research (2018)
The developed PBPK model adequately predicted the pharmacokinetics of fimasartan, amlodipine, and hydrochlorothiazide, suggesting that the model can be used to further investigate the DDI potential of each drug.
Keyphrases
  • adverse drug
  • hypertensive patients
  • drug induced
  • blood pressure