Malondialdehyde acetaldehyde adduction of surfactant protein D attenuates SARS-CoV-2 spike protein binding and virus neutralization.

Abenaya MuralidharanChristopher BauerDawn M KatafiaszDanielle PhamOpeoluwa O OyewoleM Jane MorwitzerEnakshi RoyKristina L BaileySt Patrick ReidTodd A Wyatt

Published in: Alcoholism, clinical and experimental research (2022)

Overall, MAA adduction of SPD, a consequence of alcohol overconsumption, represents one mechanism of compromised lung innate defense against SARS-CoV-2, highlighting a possible mechanism underlying COVID-19 severity and related mortality in patients who misuse alcohol.

Keyphrases

sars cov
respiratory syndrome coronavirus
immune response
binding protein
protein protein
coronavirus disease
alcohol consumption
amino acid
chronic pain
cardiovascular events
type diabetes
small molecule
dna binding
coronary artery disease
transcription factor