Response to sequential treatment with prednisolone and vigabatrin in infantile spasms.
Winston DzauSally ChengPenny SnellMichael FaheyIngrid Eileen SchefferA Simon HarveyKatherine B HowellPublished in: Journal of paediatrics and child health (2022)
We confirm higher rates of spasm cessation with initial treatment with prednisolone than vigabatrin and nonstandard therapy. Non-use of prednisolone as first treatment in over one third of infants highlights a concerning treatment gap. The UKISS treatment sequence has high overall treatment response (total 93/112; 83%), with similar benefit of subsequent prednisolone 60 mg/day and vigabatrin in prednisolone 40 mg/day non-responders.