Smooth Muscle Mineralocorticoid Receptor Promotes Hypertension After Preeclampsia.
Lauren A BiwerQing LuJaime IbarrolaAlec StepanianJoshua J ManBrigett V CarvajalNicholas D CamardaZsuzsanna K ZsengellerGeraldine SkurnikEllen W SeelyS Ananth KarumanchiIris Z JaffePublished in: Circulation research (2023)
These data support that sFlt1-induced vascular injury during preeclampsia produces a persistent state of enhanced sensitivity of SMC-MR to activation. This contributes to postpartum hypertension in response to common stresses and supports testing of MR antagonism to mitigate the increased cardiovascular risk in women after PE.
Keyphrases
- smooth muscle
- blood pressure
- pregnancy outcomes
- early onset
- contrast enhanced
- magnetic resonance
- high glucose
- polycystic ovary syndrome
- diabetic rats
- electronic health record
- pregnant women
- big data
- magnetic resonance imaging
- type diabetes
- endothelial cells
- arterial hypertension
- adipose tissue
- cervical cancer screening
- oxidative stress
- deep learning