Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury.

Yuhao XuLimoran TangChao ZhouLiang SunYujie HuZhi ZhangShengnan XiaXinyu BaoHaiyan YangYun Xu

Published in: CNS neuroscience & therapeutics (2024)

ADORA3 antagonist alleviates chronic ischemic WMI by modulating myelin clearance of microglia, which may be a potential therapeutic target for the treatment of VaD.

Keyphrases

white matter
inflammatory response
neuropathic pain
ischemia reperfusion injury
multiple sclerosis
mouse model
signaling pathway
lipopolysaccharide induced
oxidative stress
spinal cord injury
combination therapy
brain injury
blood brain barrier