Shared genetic aetiology of Alzheimer's disease and age-related macular degeneration by APOC1 and APOE genes.

Xueli ZhangZhuoting ZhuYu HuangXianwen ShangTerence J O'BrienPatrick KwanJason HaMingguang HeShunming LiuXiayin ZhangKaterina KiburgYining BaoJing WangHonghua YuMingguang HeLei Zhang

Published in: BMJ neurology open (2024)

In this study, we confirmed the genetic pleiotropy between AD and AMD and identified APOC1 and APOE as pleiotropic genes. Further, the integration of multiomics data identified ZNF131, ADNP2 and HINFP as novel diagnostic biomarkers for AD and AMD.

Keyphrases

age related macular degeneration
genome wide
cognitive decline
dna methylation
high fat diet
copy number
genome wide identification
bioinformatics analysis
mild cognitive impairment
big data
gene expression
type diabetes
insulin resistance
skeletal muscle