Adiponectin Ameliorates Hyperglycemia-Induced Retinal Endothelial Dysfunction, Highlighting Pathways, Regulators, and Networks.
Sumbul BushraDuaa W Al-SadeqRedwana BariAfifah SaharaAmina FadelNasser Moustafa RizkPublished in: Journal of inflammation research (2022)
Adiponectin significantly counteracts hyperglycemia at various cellular and molecular levels, reducing its impact on the pathophysiological progression towards DR in vitro using HMRECs. Adiponectin ameliorates inflammatory response, oxidative stress, and endothelial barrier dysfunction using a causal network of NFBk complex, TNF, and HMGB1 and integrin pathways.
Keyphrases
- diabetic rats
- oxidative stress
- inflammatory response
- metabolic syndrome
- insulin resistance
- mouse model
- dna damage
- rheumatoid arthritis
- ischemia reperfusion injury
- optical coherence tomography
- induced apoptosis
- transcription factor
- lipopolysaccharide induced
- diabetic retinopathy
- high glucose
- single molecule
- toll like receptor
- immune response
- drug induced
- skeletal muscle
- heat shock
- signaling pathway
- heat stress
- endoplasmic reticulum stress
- cell adhesion