Ultrasonic-assisted-synthesis of isoindolin-1-one derivatives.
Muhammad Idham Darussalam MardjanMuhamad Fadhly HariadiIndah Mutiara PutriNilna Amalia MusyarrofahMuflihah Salimahnull PriatmokoBambang PurwonoLaurent CommeirasPublished in: RSC advances (2022)
A small library of 3-hydroxyisoindolin-1-ones has been prepared from 3-alkylidenephtalides under ultrasonic irradiation. This practical synthesis is featured by group tolerance, high efficiency and yields. The reaction can also be performed in multigram scale and be further extended to access other motifs of isoindolin-1-ones in a one-pot fashion.
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