α1-Antitrypsin attenuates acute rejection of orthotopic murine lung allografts.

Tomoyuki NakagiriSabine WrengerKokilavani SivaramanFabio IusTobias GoeckePatrick ZardoVeronika GrauTobias WelteAxel HaverichAnn-Kathrin KnöfelSabina Janciauskiene

Published in: Respiratory research (2021)

Therapy with AAT suppresses the acute rejection after LuTx in a mouse model. The beneficial effects seem to involve anti-protease and immunomodulatory activities of AAT.

Keyphrases

liver failure
mouse model
respiratory failure
drug induced
aortic dissection
signaling pathway
hepatitis b virus
stem cells
intensive care unit
mesenchymal stem cells
mechanical ventilation