Kidney Function in Patients with Ovarian Cancer Treated with Poly (ADP-ribose) polymerase (PARP) Inhibitors.

Shruti GuptaPaul E HannaTianqi OuyangKarla Sofia YamadaRani SawtellQiyu WangNurit Katz-AgranovLea FeghaliCarolyn N KrasnerSara BouberhanCesar M CastroMeghan E Sise

Published in: Journal of the National Cancer Institute (2023)

AKI is common following PARPi initiation, as is a transient decline in eGFR; however, sustained AKI directly attributable to the PARPi and long-term eGFR decline are uncommon.

Keyphrases

small cell lung cancer
acute kidney injury
epidermal growth factor receptor
tyrosine kinase
dna damage
dna repair
cerebral ischemia
oxidative stress
structural basis
newly diagnosed