Autonomous Calcium Signaling in Human and Zebrafish Podocytes Controls Kidney Filtration Barrier Morphogenesis.

Lydia DjenouneRitu TomarAude DorisonIrene GhobrialHeiko SchenkJan HegermannLynne Beverly-StaggsAlejandro Hidalgo-GonzalezMelissa H LittleIain A Drummond

Published in: Journal of the American Society of Nephrology : JASN (2021)

These findings establish podocyte cell-autonomous calcium signaling as a prominent and evolutionarily conserved feature of podocyte differentiation and demonstrate its requirement for podocyte foot process formation.

Keyphrases

diabetic nephropathy
high glucose
endothelial cells
single cell
deep learning
transcription factor
cell therapy
neural network