The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development.

Rob C M de JongMark M EwingMargreet R de VriesJacco C KarperAntonius J N M BastiaansenHendrika A B PetersFabiana BaghanaPeter J van den ElsenCéline GongoraJ Wouter JukemaPaulus H A Quax

Published in: PloS one (2017)

These results identify a vital role for the lysine acetyltransferase PCAF in the regulation of local inflammation after arterial injury and likely the subsequent vSMC proliferation, responsible for intimal hyperplasia.

Keyphrases

oxidative stress
dna methylation
gene expression
signaling pathway
amino acid