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Circular eight-room maze for assessing spatial learning and memory functions in rats: An example using a traumatic brain injury model.

Chi-Chun ChenYu-Rui Hung
Published in: Computers in biology and medicine (2024)
Experimental data indicated a substantial increase in irregular search behavior in the TBI group over time, suggesting deterioration in cognitive function and an inability to accurately recall the food room. Conversely, the sham group exhibited consistent search trajectories, typically following the walls and rapidly locating the food room. Moreover, their room entries were guided by memory rather than by chance. Compared with traditional maze tests, this system's strengths lie in its ability to provide more quantitative data and vividly portray behavioral patterns. Therefore, the proposed CERM system can be used as an effective tool for cognitive assessment.
Keyphrases
  • traumatic brain injury
  • electronic health record
  • big data
  • high resolution
  • human health
  • machine learning
  • severe traumatic brain injury
  • clinical trial
  • climate change
  • deep learning