Near-Infrared Monoamine Oxidase Inhibitor Biodistribution in a Glioma Mouse Model.

Ronald W IrwinAlesi R EscobedoJean C Shih

Published in: Pharmaceutical research (2021)

Intravenous 5 mg/kg was optimal dose to target brain tumor and identified off-target organs of concern: lungs, liver, and kidneys. These results demonstrate the biodistribution and optimal dose range of NMI for treatment and diagnostic monitoring of glioma.

Keyphrases

mouse model
pet imaging
high dose