Proteomics and Transcriptomics of the Hippocampus and Cortex in SUDEP and High-Risk SUDEP Patients.
Dominique Frances LeitnerJames D MillsGeoffrey PiresArline FaustinEleanor DrummondEvgeny KanshinShruti NayakManor AskenaziChloe VerducciBei Jun ChenMichael JanitzJasper J AninkJohannes C BaayenSander IdemaErwin Alexander van VlietSasha DevoreDaniel FriedmanBeate DiehlCatherine A ScottRoland ThijsThomas M WisniewskiBeatrix UeberheideMaria ThomEleonora M A AronicaOrrin DevinskyPublished in: Neurology (2021)
The SUDEP proteome and high-risk SUDEP transcriptome were similar to those in other patients with epilepsy in hippocampus and cortex, consistent with diverse epilepsy syndromes and comorbid conditions associated with SUDEP. Studies with larger cohorts and different epilepsy syndromes, as well as additional anatomic regions, may identify molecular mechanisms of SUDEP.